Notwithstanding their essential contribution to innovation, job creation and local development, MSMEs across the southern Mediterranean are confronted with a number of problems that hamper their growth. Ayadi & De Groen (2013) assessed what is required to unlock the growth potential of the most promising MSMEs. Based on a thorough literature review and inputs from economic experts from the countries under investigation, a questionnaire was designed to identify the problems that confront MSMEs with high-growth potential. Six areas were identified as key potential obstacles that could hinder MSME development: administrative, legal and tax regulations; infrastructure (communications, utility services, roads and transport); access to financial instruments; clients and suppliers; availability of skills; and informality and corruption.